Triptolide inhibits the Apoptosis and Reactive Oxygen Species Production in Hydrogen Peroxide-Treated Nasal Epithelial Cells by Regulating PTEN/PI3K/AKT Signaling Pathway

Chronic rhinosinusitis is a chronic inflammatory condition that caused by many factors. However, the underlying mechanism of remains unclear. The current study focused on roles triptolide hydrogen peroxide treated nasal epithelial cells and underling mechanism. Hydrogen human were cultured different concentrations triptolide, cell growth death determined counting kit-8 flow cytometry methods. Moreover, effects expression superoxide dismutase as well malondialdehyde in evaluated enzyme-linked immunosorbent assay analysis. Furthermore, phosphatase tensin homolog deleted chromosome 10/phosphatidylinositol 3-kinase/protein kinase B molecules have been examined Western blot method. We found treatment markedly inhibited dose-dependent manner could reverse effect induced peroxide. significantly decreased apoptosis manner; moreover, reduced levels dose dependent manner. Finally, downregulated 10 upregulated phosphatidylinositol 3-kinase related signalling vitro. In conclusion, may exert anti-apoptotic anti-oxidative behaviors via affecting signaling. results work provide new evidence for research management rhinosinusitis.